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Principal Investigator

Lab Members

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Principal Investigator

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  EDUCATION

  • 1987 - 1991             B.S.  College of Pharmacy, Seoul National University   

  • 1991 - 1993             M.S.  Major in Pharmacology, Department of Pharmacy,                                                           Graduate School, Seoul National University

  • 1993 - 1997             Ph.D. Major in Pharmacology, Department of Pharmacy,                                                         Graduate School, Seoul National University​​​​​​​​


  CAREER

​​   

  • 2011  -  현재          교수, 가톨릭대학교 약학대학​

  • 2004  -  2011         조교수/부교수, 영남대학교 약학대학

  • 1999  -  2003         Postdoctoral Fellow/Research Associate,  Johns Hopkins University    

  • 2020  -  현재          BK21FOUR 스마트파마 미래인재 양성사업팀 팀장

  • 2025                      대한약학회 교육위원장, 한국독성학회 편집위원장(Toxicological                                                Research, Editor-in-Chief),                                                                                                       Archives Pharmacal Research (Associate Editor),                                                                  한국응용약물학회 기금관리위원장,                                                                                            식품의약품안전평가원 위해성평가 전문위원

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  SELECTED PUBLICATIONS (from 2019)

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 Listed in Stanford/Elsevier’s World’s Top 2% Scientists (Career & 2024) 

H-index 50

Scopus : https://www.scopus.com/authid/detail.uri?authorId=7006129122

​Orcid : https://orcid.org/0000-0001-6254-2516

  • Kim SK, Bae GS, Bae T, Ku SK, Choi BH, Kwak MK (2024) Renal microRNA-144-3p is associated with transforming growth factor-β1-induced oxidative stress and fibrosis by suppressing the NRF2 pathway in hypertensive diabetic kidney disease. Free Radic Biol Med 225:546-559 (IF=7.1, JIF 랭킹 상위 7.8%)

  • Lee JH, Hallis SP, Kwak MK (2024) Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation. Arch Pharm Res. 47(5):465-480 (F=6.9, JIF 랭킹 상위 3.5%).

  • Ham S, Choi BH, Kwak MK (2024) NRF2 signaling and amino acid metabolism in cancer. Free Radic Res. 58(10): 648-661 (IF=3.6)

  • Bae T, Hallis SP, Kwak MK (2024) Hypoxia, Oxidative Stress, and the Interplay of HIFs and NRF2 Signaling in Cancer. Exp Mol Med. 56(3):501-514 (IF=9.5, JIF 랭킹 상위 6.6%)

  • Hallis SP, Kim JM, Kwak MK (2023) Emerging Role of NRF2 Signaling in Cancer Stem Cell phenotype. Mol Cells 46(3):153 (IF=3.7)

  • Hallis SP, Kim SK, Lee JH, Kwak MK (2023) Association of NRF2 with HIF-2α-induced cancer stem cell phenotypes in chronic hypoxic condition. Redox Biol 60:102632 (F=10.7, JIF 랭킹 상위 5.3%).

  • Choi BH, Ryoo I, Shim KH, Ahn HJ, Lee YJ, Kwak MK (2022) High Levels of Hyaluronic Acid Synthase-2 Mediate NRF2-Driven Chemoresistance in Breast Cancer Cells. Biomol Ther 30(4):368.

  • Park J, Kim SK, Hallis SP, Choi BH, Kwak MK (2022) Role of CD133/NRF2 Axis in the Development of Colon Cancer Stem Cell-Like Properties. Front Oncol 2021.808300

  • Choi BH, Kim J, Kwak MK (2021) The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenance. Arch Pharm Res 44(3):263-280 (F=6.9, JIF 랭킹 상위 3.5%).

  • Ryu D, Lee JH, Kwak MK (2020) level is negatively correlated with TGF-beta 1-induced lung cancer motility and migration via NOX4-ROS signaling Arch Pharm Res 43(12): 1297 (F=6.9, JIF 랭킹 상위 3.5%).

  • Kim SK, Kim G, Choi BH, Ryu D, Ku SK, Kwak MK (2021) Negative correlation of urinary miR-199a-3p level with ameliorating effects of sarpogrelate and cilostazol in hypertensive diabetic nephropathy. Biochem Pharmacol. 184:114391 (IF=5.3, JIF 랭킹 상위 9.7%)

  • Lee S, Hallis SP, Jung KA, Ryu D, Kwak MK (2019) Impairment of HIF-1α-mediated metabolic adaption by NRF2-silencing in breast cancer cells. Redox Biol. 24: 101210 (F=10.7, JIF 랭킹 상위 5.3%).

  • Song MK, Lee JH, Ryoo IG, Lee SH, Ku SK, Kwak MK (2019) Bardoxolone ameliorates TGF-β1-associated renal fibrosis through Nrf2/Smad7 elevation. Free Radic Biol. Med 138: 33 (IF=7.1, JIF 랭킹 상위 7.8%)​​​

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Lab Member

Tae-Geun Bae. Ph. D
Research Professor l

- Ph.D
- Research interest: Gene editing (CRISPR), Cancer

Steffanus Pranoto Hallis
 Research Fellow l

- Ph.D 
- Research interest: NRF2-HIF regulation, Renal carcinoma

Seung-Ki Kim
Graduate Student l

- Ph.D student
- Research interest: Renal pathology, Urinary biomarker

Cherry Ng
Graduate Student l

- MS  student
- Research interest: Cancer migration, Secretome

Gwang-Sun Bae
Graduate Student l

- MS  student
- Research interest: Kidney disease, microRNA regulation

So-Hyun Park

Graduate Student l 

 
 
- MS, Ph.D Integrate student

- Research interest
: Cancer, microRNA regulation

Bum-Jun Jang

Graduate Student l



-  MS, Ph.D Integrate student

Yu-Bin Park

UnderGraduate Student l 

 
 
- Undergraduate  student
 

ALUMNI

In-Geun Ryoo Ph.D
Dong-Hyeok Kim M.S.
Su-Jin Lee M.S.
Sang-Hwan Lee M.S.
Geon Kim M.S.
Kyeong-Ah Jung Ph.D.
Jeong-Hyeon Park M.S.
Dong-Hyun Kim M.S.
Da-Young Ryu Ph.D.

Bo-Hyun Choi Ph.D
Hyuk-Sang Jeong M.S.
Min-Gu Song M.S.
Eu-Gene Hur M.S.
Tae-Hyoung Kim M.S.
Sang-Hwan Lee M.S.
Chang-Won Nam M.S.
Dong-Ha Shin M.S.
Jong-In Lee M.S.

Min-Kyun Song M.S.
Gi-Seong Shim M.S.
Aram You M.S.
Hyun-Min Park M.S.
Jeong-Min Cho M.S.
Sarala Manandhar Ph.D.

Jin-Myung Kim M.S.

Ji-Min Park M.S.
Dong-Hyeok Kwak M.S

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